Artificial Intelligence

The Genesis Mission is a defining moment in American history, marshalling the full resources of our nation to secure technological leadership in the age of artificial intelligence. This initiative combines DOE's and the National Labs' world-class supercomputing power, unique scientific data, and AI capabilities into a single integrated system designed to dramatically accelerate scientific discovery. As strategic competitors race to dominate AI, the Genesis Mission ensures the United States will not only keep pace but will lead, accelerating breakthroughs in energy independence, national security, and critical technologies that will shape the future for generations to come. Learn more at the Genesis Mission website.

How DOE is advancing AI Innovation

AI is a broad technology area that includes machine-based systems that can make predictions, recommendations, or decisions. These systems are trained to identify patterns in data and they can then generalize to answer new questions, generate text or other media, or make autonomous decisions.

Laying the foundations for AI 

Since the 1960s, DOE has sponsored basic research in applied mathematics and computer science that laid the foundations for AI. Over the decades, DOE’s multi-pronged strategy of investments in hardware design, basic research for innovative AI techniques, and application development has enabled today's AI revolution.

Partnering with industry   

DOE has a storied track record of working with industry on innovative hardware designs for advanced computing resources, including AI. Through the Exascale Computing Project, DOE, alongside its industry partners, successfully achieved a 200x improvement in energy efficiency for high-performance computing. Critical components of today’s Graphic Processing Units – specialized chips that are used in training the AI models we rely on today – were initially developed via DOE’s early investments in high-performance computing.

Powering AI with scientific data

Reliant AI also requires high-quality data and DOE’s experimental user facilities generate unparalleled scientific data sets – including data for high energy, nuclear and plasma physics, characterization of materials with X-rays and neutrons, and genomic analysis for biotechnology. To maximize this data's impact, DOE enhances the reliability, robustness, and rigor of AI algorithms and methods to support their use in scientific research. 

Accelerating discovery with AI

Going forward, DOE will build an integrated AI platform to combine the Department's world-class computing, unique scientific datasets, experimental facilities, and quantum computing to drastically reduce the time-to-solution for today's most challenging scientific and national-security problems. In short, DOE will shrink discovery cycles from years to months and validate the most promising AI technologies.

How AI Innovation Advances DOE's Mission

DOE’s investments in AI span the entire department, from scientific discovery to energy applications to national security. We have been applying AI to DOE’s mission areas for decades, with individual research programs focusing on enhancing the analysis of data across disciplines to maximize its scientific impact.
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    DOE's world-leading supercomputers and expert workforce are uniquely positioned to leverage the power of AI for science at scale.
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    DOE is at the forefront of applying AI to address key challenges across the energy sector.
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  • Purple nodes in a web
    The Department of Energy's National Nuclear Security Administration (NNSA) has a critical mission: safeguarding U.S. national security by maintaining the safety, security, and reliability of the nuclear stockpile while preventing the proliferation of nuclear weapons and materials.
    December 8, 2025

American Infrastructure Powering AI

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AI applications require robust energy infrastructure to drive growth and innovation. Data centers are projected to consume up to 9% of total U.S. electricity demand by 2030, with the largest growth dedicated to developing AI capabilities and scaling AI applications to millions of consumers.

Meeting the energy demands of data centers

DOE possesses the technical resources to support the data center developers, utilities, state and local officials, and communities, and the Department is committed to collaborating with stakeholders to overcome the challenges of growing demand.

Public-private partnerships for American competitiveness

We announced plans to partner with private-sector developers to develop cutting-edge AI data centers and energy-generation projects on DOE lands and launched the Speed to Power Initiative to accelerate the speed of large-scale grid infrastructure project development for both transmission and generation. These initiatives help ensure the United States has the power needed to win the global AI race while continuing to meet growing demand for affordable, reliable, and secure energy.

Improving AI applications

DOE is also committed to improving the efficiency of AI applications, building on a long history of supercomputer deployment, with multiple research efforts focused on improving the performance of individual chips, algorithms for software, computer systems, and data centers. And AI can also be part of the solution. DOE released the PermitAI tool to improve the speed and quality of federal environmental permitting and we continue to explore ways that AI tools can deploy new energy generation, secure the power grid, and reduce the costs of next-generation energy technologies.

Responsible AI

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    While AI brings enormous potential to improve American innovation and prosperity, we also recognize the risks inherent in such technology. AI systems may generate incorrect, unverifiable, and potentially harmful outputs, and any use of AI technology must properly understand and mitigate those risks.

    DOE's role in advancing AI security and reliability

    DOE is helping advance the science of AI risk and build a secure and reliable AI ecosystem. 

    • Adversarial testing: We are leading the way by developing adversarial testing of AI models and systems, particularly against chemical, biological, radiological, and nuclear threats, as well as against cyber threats to the power grid.
    • AI testbeds: We are building AI testbeds to provide developers safe and secure ways to test new AI tools, hardware, and algorithms.
    • Privacy-enhancing technologies: We are partnering with academic researchers and other federal agencies to develop privacy-enhancing technologies that will allow widespread deployment of AI tools while mathematically protecting the underlying data. 
    • Model assessment: We are leading the way with assessments of the scientific capabilities of AI models and understanding model thresholds and performance.

     

    DOE’s work on these key issues is aligned with a national strategy laid out in Executive Orders, Management Memos, and National Security Memoranda.

  • DOE is responsible for implementing relevant White House directives related to AI. This involves aligning DOE's AI research, development, deployment, and governance efforts with the broader AI strategy and guidance. DOE actively participates in interagency AI initiatives, contributing its expertise in energy, science, and national security to inform government-wide AI policies and initiatives. This collaborative approach ensures that AI advancements are strategically leveraged across various sectors while addressing potential risks.

Supporting Offices

AI is a crosscutting technology that touches every part of DOE’s mission. The Office of Critical and Emerging Technologies coordinates AI activities across DOE and the national laboratories.