The Portsmouth Site, located in Piketon, Ohio, consisted of four main areas historically totaling more than 3,700 acres: the former gaseous diffusion plant, centrifuge facilities, depleted uranium hexafluoride conversion (DUF6) facility and On-Site Waste Disposal Facility (OSWDF). The largest of the three areas is the former gaseous diffusion plant, which consists of three main process buildings (X-333, X-330 and X-326) which housed the gaseous diffusion process equipment, as well as hundreds of supporting facilities. A seven-mile perimeter road contains the process buildings and over 400 structures and facilities.
The OSWDF is located northeast outside of the perimeter road and has a 300-acre footprint, including support facilities. More than 2,200 workers are employed at the site making it one of the largest employment drivers in the region. Currently, at the site, workers are continuing deactivation of the X-330 Process Building and are close to complete with deactivation at the X-333 Process Building.
PortsDemo - Environmental Monitoring
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Portsmouth News
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SB Energy, a SoftBank Group company, announced a unique public-private partnership to construct the world’s largest artificial intelligence data center at the U.S. Department of Energy’s Portsmouth Site, and committed to build 10 gigawatts of new power generation that will connect to the local grid to prevent costs to American families. March 24, 2026March 24, 2026 -
Oversized heavy shears and custom-made excavators will be used to efficiently dismantle the X-333 Process Building at the U.S. Department of Energy’s Portsmouth Site. March 24, 2026March 24, 2026 -
- Science & Innovation
- Artificial Intelligence
The Trump Administration is Bringing New Power Online, Lowering Energy Prices, Creating Thousands of Jobs, and Modernizing Infrastructure in Southern OhioMarch 20, 2026 -
- Science & Innovation
- Artificial Intelligence
The U.S. Department of Energy, alongside the U.S. Department of Commerce, today announced a unique public-private partnership with SoftBank and AEP Ohio to redevelop DOE land, modernize energy infrastructure, and develop advanced computing in Southern Ohio.March 20, 2026