The Portsmouth Site, located in Piketon, Ohio, consisted of four main areas historically totaling more than 3,700 acres: the former gaseous diffusion plant, centrifuge facilities, depleted uranium hexafluoride conversion (DUF6) facility and On-Site Waste Disposal Facility (OSWDF). The largest of the three areas is the former gaseous diffusion plant, which consists of three main process buildings (X-333, X-330 and X-326) which housed the gaseous diffusion process equipment, as well as hundreds of supporting facilities. A seven-mile perimeter road contains the process buildings and over 400 structures and facilities.
The OSWDF is located northeast outside of the perimeter road and has a 300-acre footprint, including support facilities. More than 2,200 workers are employed at the site making it one of the largest employment drivers in the region. Currently, at the site, workers are continuing deactivation of the X-330 Process Building and are close to complete with deactivation at the X-333 Process Building.
PortsDemo - Environmental Monitoring
The safety of our workers, our community and the environment is DOE’s top priority. The Department has a robust environmental monitoring program that meets or exceeds state and national regulatory standards.
Portsmouth News
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The Trump Administration is Bringing New Power Online, Lowering Energy Prices, Creating Thousands of Jobs, and Modernizing Infrastructure in Southern OhioMarch 20, 2026 -
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The U.S. Department of Energy, alongside the U.S. Department of Commerce, today announced a unique public-private partnership with SoftBank and AEP Ohio to redevelop DOE land, modernize energy infrastructure, and develop advanced computing in Southern Ohio.March 20, 2026 -
Successful cleanup and reuse efforts underway at the Oak Ridge, Paducah, and Portsmouth sites are vividly illustrating the Office of Environmental Management’s ability to successfully deliver its vision of nuclear restoration and revitalization across the DOE complex, federal and contractor leaders said. March 17, 2026March 17, 2026
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Radiation Technician Camron Griffey demonstrated that always being prepared can save a life. March 17, 2026March 17, 2026