To mimic complex natural proteins' capabilities as sensors, catalysts, and more using synthetic materials that can withstand industrial conditions, scientists must first know how to finesse the building blocks they'll use. Molecular Foundry staff worked with scientists to discover a new design rule that controls the way in which polymer building blocks adjoin to form the backbones that run the length of tiny biomimetic sheets.
Understanding the rules that govern how the nanosheets self-assemble could be used to piece together complex sheet structures and others, such as nanotubes and crystalline solids, that could be customized into incredibly sensitive chemical detectors or long-lasting catalysts, to name a few possibilities.
Scientists aspire to build nanostructures that mimic the complexity and function of nature's proteins, but are made of durable and synthetic materials. These microscopic widgets could be customized into incredibly sensitive chemical detectors or long-lasting catalysts, to name a few possible applications. But as with any craft that requires extreme precision, researchers must first learn how to finesse the materials they'll use to build these structures. A recent discovery by scientists at the Molecular Foundry is a big step in this direction. The researchers discovered a design rule that enables a recently created material to exist. The material is a peptoid nanosheet. It's a flat structure only two molecules thick, and it's composed of peptoids, which are synthetic polymers closely related to protein-forming peptides. The design rule controls the way in which polymers adjoin to form the backbones that run the length of nanosheets. Surprisingly, these molecules link together in a counter-rotating pattern not seen in nature. This pattern allows the backbones to remain linear and untwisted, a trait that makes peptoid nanosheets larger and flatter than any biological structure. The Molecular Foundry scientists say this never-before-seen design rule could be used to piece together complex nanosheet structures and other peptoid assemblies such as nanotubes and crystalline solids. What's more, they discovered it by combining computer simulations at National Energy Research Scientific Computing Center, another DOE user facility located at Berkeley Lab, with x-ray scattering and imaging methods to determine, for the first time, the atomic-resolution structure of peptoid nanosheets.
Molecular Foundry, Berkeley Lab
Portions of this work were done as a user project at the Molecular Foundry at Lawrence Berkeley National Laboratory, supported by the Office of Science, Office of Basic Energy Sciences, of the US Department of Energy under contract no. DE-AC02-05CH11231. R.V.M., T.K.H., C.P., E.J.R., A.B., R.N.Z., and S.W. were supported by the Defense Threat Reduction Agency under contract no. IACRO-B0845281. C.P. was also supported by the Natural Sciences and Engineering Research Council of Canada (NSERC PDF). R.N.Z. and S.W. were also supported by the Office of Science, Office of Basic Energy Sciences, of the US Department of Energy under contract no. DE-AC02-05CH11231. We thank G. K. Olivier for providing the atomic force microscopy data. This work used resources of the National Energy Research Scientific Computing Center, which is supported by the Office of Science of the US Department of Energy under contract no. DE-AC02-05CH11231. Quantum-mechanical calculations were carried out on the High Performance Computing resources at New York University Abu Dhabi.
R. V. Mannige, T. K. Haxton, C. Proulx, E. J. Robertson, A. Battigelli, G. L. Butterfoss, R. N. Zuckermann and S. Whitelam, "Peptoid nanosheets exhibit a new secondary-structure motif." Nature 526, 7573 (2015).