PF 2025-12 (AL 2025-03) Implementation of the Framework for Nucleic Acid Synthesis Screening

DATE: November 22, 2024

TO: HCAs/Procurement Directors/Contracting Officers
FROM: Director, Contract and Financial Assistance Policy Division, Office of Policy, Office of Acquisition Management

SUMMARY: This Policy Flash transmits Acquisition Letter (AL) AL-2025-03. The Acquisition Letter provides guidance to Contracting Officers regarding contracts that involve the procurement of synthetic nucleic acids and benchtop nucleic acid synthesis equipment using federal life sciences funding. The AL also transmits new DOE corporate clause DOE-H-2088 Implementation of the Framework for Nucleic Acid Synthesis Screening, which requires contractors to obtain synthetic nucleic acids – or devices capable of synthesizing them – from providers or manufacturers that attest to implementing 2024 Office of Science and Technology Policy (OSTP) Framework for Nucleic Acid Synthesis Screening. 

For DOE questions concerning this policy flash, please e-mail DOE_oapmpolicy@hq.doe.gov.

Attachment:

AL 2025-03 Implementation of the Framework for Nucleic Acid Synthesis Screening