The Portsmouth Site, located in Piketon, Ohio, consisted of four main areas historically totaling more than 3,700 acres: the former gaseous diffusion plant, centrifuge facilities, depleted uranium hexafluoride conversion (DUF6) facility and On-Site Waste Disposal Facility (OSWDF). The largest of the three areas is the former gaseous diffusion plant, which consists of three main process buildings (X-333, X-330 and X-326) which housed the gaseous diffusion process equipment, as well as hundreds of supporting facilities. A seven-mile perimeter road contains the process buildings and over 400 structures and facilities.
The OSWDF is located northeast outside of the perimeter road and has a 300-acre footprint, including support facilities. More than 2,200 workers are employed at the site making it one of the largest employment drivers in the region. Currently, at the site, workers are continuing deactivation of the X-330 Process Building and are close to complete with deactivation at the X-333 Process Building.
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Portsmouth News
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SB Energy, a SoftBank Group company, recently announced a unique public-private partnership to construct the world’s largest artificial intelligence data center on leased land at the U.S. Department of Energy’s Portsmouth Site. April 7, 2026April 7, 2026 -
Crews at the U.S. Department of Energy’s Portsmouth Site are deactivating a unique facility that once housed more than 100 specialized laboratories, part of a broader plan to shrink the legacy footprint to enable long‑term economic growth, community revitalization and high‑quality jobs for American workers. April 7, 2026April 7, 2026 -
Powers AI Data CenterMarch 24, 2026 -
Oversized heavy shears and custom-made excavators will be used to efficiently dismantle the X-333 Process Building at the U.S. Department of Energy’s Portsmouth Site. March 24, 2026March 24, 2026