CX-101141 Engineered reversal of the β-oxidation cycle in clostridia for the synthesis of fuels and chemicals

Award Number: DE-EE0008354CX(s) Applied: A9, B3.6Bioenergy Technologies OfficeLocation(s): ILOffice(s): Golden Field Office

Office of NEPA Policy and Compliance

July 12, 2018
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Award Number: DE-EE0008354
CX(s) Applied: A9, B3.6
Bioenergy Technologies Office
Location(s): IL
Office(s): Golden Field Office

The U.S. Department of Energy (DOE) is proposing to provide funding to Northwestern University to engineer clostridia to ferment synthesis gas (syngas) from lignocellulosic biomass, into advanced fuels and bioproducts. Fuels, additives and chemical building blocks, including hexanediol (HDO), hexanol and decanol would be produced via reversal of the β-oxidation cycle (r-BOX) at >80L scale. Improvements in the processes surrounding r-BOX would help to advance the fermentation technology from Technical Readiness Level 2 (TRL-2) to TRL-4.