The Mission of the Office of Technology Transitions is to expand the public impact of the department’s research and development (R&D) portfolio to advance the economic, energy and national security interests of the nation. OTT is the front door to DOE’s products, facilities and expertise. The office integrates “market pull” into its planning to ensure the greatest return on investment from DOE’s R&D activities to the taxpayer.

Hosting one of the world’s largest science research enterprises, the U.S. Department of Energy (DOE) helps power and secure America's future through technological advancement and strategic support. DOE's R&D capabilities, and the innovations they enable, help maintain the United States’ role as the global leader in science and technology. In particular, technology transfer supports the maturation and deployment of DOE-powered innovation, providing ongoing economic, security and environmental benefits for all Americans.

In 2015, Secretary of Energy Ernest Moniz authorized the formation of the Office of Technology Transitions, which is responsible for developing and overseeing delivery of the DOE strategic vision and goals for technology commercialization and engagement with the business and industrial sectors across the US, such as manufacturing, energy and technology. In 2018, Secretary Rick Perry elevated OTT’s mission with the establishment of the Chief Commercialization Officer, who also serves as OTT’s Director.