The Savannah River Site (SRS) is a key U.S. Department of Energy (DOE) industrial complex dedicated to; environmental cleanup, nuclear weapons stockpile stewardship, and nuclear materials disposition, in support of the U.S. nuclear non-proliferation efforts. The site also develops and deploys technologies to support radiological and chemical cleanup activities following approximately 50 years of producing materials used for nuclear weapons, primarily plutonium and tritium.

DOE’s Savannah River Operations Office (DOE-SR) serves as the landlord for site resources and is responsible for oversight of the DOE's Office of Environmental Management (EM) operations and the work performed by SRS contractors.

The National Nuclear Security Administration (NNSA) operates facilities at the SRS to supply and process tritium, a radioactive form of hydrogen that is a key component of nuclear weapons. SRS loads tritium and non-tritium reservoirs; processes reservoirs; and recycles, extracts, and enriches tritium gas. SRS also plays a key role in NNSA's nonproliferation missions. 

DOE-SR performs oversight of specialized contractors that manage SRS operations. These contractors include: Savannah River Nuclear Solutions, the site management and operations contractor; Savannah River Remediation, the liquid waste system contractor, Centerra, the site security contractor and Parsons, the Salt Waste Processing Facility contractor. 

The Savannah River National Laboratory is the applied research and development laboratory at SRS and is the DOE Office of Environmental Management’s laboratory.