On January 25thand 26th, the Department of Energy’s Advanced Manufacturing Office (AMO) held the first in a series of workshops on different topics related to semiconductor research and development (R&D). This workshop focused on integrated sensor system R&D for manufacturing applications. As AMO is housed within the office of Energy Efficiency and Renewable Energy (EERE), the workshop addressed not only industry needs and R&D opportunities, but also the impacts that improvements in sensor systems can have on energy efficiency and greenhouse gas production. The output of this workshop will inform AMO’s future portfolio of R&D investments, provide perspectives on trends, drivers, and challenges for next generation semiconductor sensor systems, and help the stakeholder community understand the opportunities on the horizon.