The Secretary of Energy tasked the U.S. Department of Energy (Department or DOE) Office of Enterprise Assessments to identify lessons from the response to the coronavirus disease 2019 (COVID‑19).  This report is a subset of a more extensive lessons-learned effort and focuses explicitly on identifying the senior Headquarters managers’ perspective on command, control, and communication lessons learned from the COVID-19 crisis management response.  The purpose of the overall effort is to collect and analyze COVID-19 experiences and organize them to provide management throughout the Department with a basis for enhancing planning and response to future events.