The Portsmouth Site, located in Piketon, Ohio, consisted of four main areas historically totaling more than 3,700 acres: the former gaseous diffusion plant, centrifuge facilities, depleted uranium hexafluoride conversion (DUF6) facility and On-Site Waste Disposal Facility (OSWDF). The largest of the three areas is the former gaseous diffusion plant, which consists of three main process buildings (X-333, X-330 and X-326) which housed the gaseous diffusion process equipment, as well as hundreds of supporting facilities. A seven-mile perimeter road contains the process buildings and over 400 structures and facilities.
The OSWDF is located northeast outside of the perimeter road and has a 300-acre footprint, including support facilities. More than 2,200 workers are employed at the site making it one of the largest employment drivers in the region. Currently, at the site, workers are continuing deactivation of the X-330 Process Building and are close to complete with deactivation at the X-333 Process Building.
PortsDemo - Environmental Monitoring
The safety of our workers, our community and the environment is DOE’s top priority. The Department has a robust environmental monitoring program that meets or exceeds state and national regulatory standards.
Portsmouth News
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Sharing knowledge of the best approaches to deactivating process buildings is one of the ways the two Portsmouth Paducah Project Office sites align to advance cleanup of former uranium enrichment plants and free up land for America’s golden era of energy dominance and strong national security. January 27, 2026January 27, 2026 -
The seamless transfer of four robotic demolition machines from the Portsmouth Site in Ohio to Oak Ridge in Tennessee illustrates how equipment sharing among cleanup sites within the U.S. Department of Energy Office of Environmental Management continues to enhance worker safety, save taxpayer dollars and reduce equipment inventory. January 20, 2026January 20, 2026 -
Thanks to their safe and successful cleanup work in 2025, the Portsmouth and Paducah sites demonstrated the strong role the U.S. Department of Energy Office of Environmental Management plays in advancing American energy dominance and innovation. December 23, 2025December 23, 2025 -
Cleanup program recently awarded performance-based fee payments to 12 of its contractors at sites across the DOE complex. December 23, 2025December 23, 2025