The Genesis Mission unites DOE National Labs, industry, academia, and more to harness AI for breakthroughs in energy dominance, discovery science, and national security.

Addressing National Science and Technology Challenges in Key Areas
DOE has identified an initial 26 national science and technology challenges to accelerate U.S. innovation and leadership. These challenges will deliver tangible benefits for the American people through the Genesis Mission’s AI platforms and partnerships.
The American Science and Security Platform
The Genesis Mission will build a complex integrated platform, connecting the world’s best supercomputers, experimental facilities, AI systems, and unique datasets.

Bringing Together World-Class Innovators
The Genesis Mission brings together cross-sector and cross-functional leading experts to solve critical challenges at unprecedented speed.
Funding Opportunities
In March 2026, DOE announced funding to advance the Genesis Mission’s efforts to tackle the nation’s most complex science and technology challenges. Get details on the Request for Applications here: The Genesis Mission: Transforming Science and Energy with AI.
For more information on funding opportunities, watch this space and sign up for our newsletter.
Genesis in the News
Get Genesis Mission updates from the Under Secretary for Science.